橡胶技术网

合成橡胶工业
CHINA SYNTHETIC RUBBER INDUSTRY
2009 Vol.32 No.6 P.471-475

 橡胶技术网

可降解弹性体聚癸二酸丙二醇柠檬酸酯的合成及其性能

王志强　 房晓敏　 徐元清　 雷丽娟　 丁涛　 张立群　

摘　要：通过癸二酸与1,2-丙二醇反应,生成中间体癸二酸聚酯二元醇,然后将中间体与柠檬酸(CA)在一定条件下熔融缩聚制得了一种可降解弹性体聚癸二酸丙二醇柠檬酸酯(PPSC).考察了催化剂和带水剂种类及酸醇比(摩尔比)对中间体合成工艺的影响,对中间体和PPSC进行了表征,初步研究了PPSC的物理机械性能和体外降解性能.结果表明,以对甲苯磺酸为催化剂、苯为带水剂,在酸醇比为1∶ 4的条件下可合成较低相对分子质量的中间体癸二酸聚酯二元醇;PPSC弹性体的玻璃化转变温度在0 ℃以下,于室温及人体温度下处于高弹态;PPSC为适度交联的、低模量高伸长的弹性体,其在37 ℃、pH值为7.4的磷酸盐缓冲溶液中具有较快的降解性(降解度超过50%).
关键词：癸二酸聚酯二元醇;柠檬酸;聚癸二酸丙二醇柠檬酸酯;弹性体;体外降解性能
分类号：TQ333.95 　文献标识码：A
文章编号：1000-1255(2009)06-0471-05

Synthesis and properties of degradable elastomer poly[(propanediol-sebacate)-citrate]

Wang Zhiqiang（Fine Chemistry and Engineering Research Institute of Henan University, Kaifeng 475001, China）　 Fang Xiaomin（Fine Chemistry and Engineering Research Institute of Henan University, Kaifeng 475001, China）　 Xu Yuanqing（Fine Chemistry and Engineering Research Institute of Henan University, Kaifeng 475001, China）　 Lei Lijuan（Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029, China）　 Ding Tao（Fine Chemistry and Engineering Research Institute of Henan University, Kaifeng 475001, China）　 Zhang Liqun（Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing 100029, China）　

Abstract：Intermidiate 1,2-propanediol-sebacate was synthesized with 1,2-propanediol and sebacic acid, then a novel degradable elastomer, poly[(propanediol-sebacate)-citrate](PPSC), was synthesized by melt phase polycondensation of 1,2-propanediol-sebacate and citric acid under under certain conditions. Effect of type of catalyst and water-carrying agent, mole ratio of sebacic acid to 1,2-propanediol on the synthesis of intermidiate were investigated, and the intermidiate and PPSC were characterized. The mechanical properties and in vitro degradation of PPSC were primarily studied. The results showed that intermidiate 1,2-propanediol-sebacate of low relative molecular mass was synthesized with toluene-p-sulfoinc acid as catalyst, benzene as 4. The glass-transition temperatures of PPSC were below 0 ℃ which confirmed that PPSC would be in a high-elastic state of ambient temperature and human body temperature. PPSC was a elastomer with moderate crosslinkage, low module and high elongation, and had rapid degradation ratio(degradation degree more than 50%) in phosphate (pH value 7.4) at 37 ℃.
Keywords：1,2-propanediol-sebacate; citric acid; poly[(propanediol-sebacate)-citrate]; elastomer; in vitro degradation

基金项目：河南省基础与前沿研究立项项目(082300430330);北京市自然科学基金重点资助项目(2061002).
作者简介：王志强(1979-),男,硕士研究生.已发表论文3篇.
作者单位：王志强（河南大学,精细化学与工程研究所,河南,开封,475001）　
　　　　　房晓敏（河南大学,精细化学与工程研究所,河南,开封,475001）　
　　　　　徐元清（河南大学,精细化学与工程研究所,河南,开封,475001）　
　　　　　雷丽娟（北京化工大学,北京市新型高分子材料制备与加工重点实验室,北京100029）　
　　　　　丁涛（河南大学,精细化学与工程研究所,河南,开封,475001）　
　　　　　张立群（北京化工大学,北京市新型高分子材料制备与加工重点实验室,北京100029）　

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收稿日期：2008年10月29日

修稿日期：2009年7月25日

出版日期：2009年11月15日