橡胶技术网

特种橡胶制品
SPECIAL PURPOSE RUBBER PRODUCTS
2007 Vol.28 No.2 P.47-53

橡胶技术网

可降解生物弹性体的研究进展

刘全勇  吴珺玥  石锐  张子政  雷丽娟  张立群  陈大福 

摘 要:可降解生物弹性体是医用高分子材料的一种,由于具有高的柔韧性和弹性,以及与人体许多软组织相匹配的力学性能,因此在生物医学上展示出巨大的应用潜力.综述了几种目前正在研究的可降解生物弹性体,还特别报道了笔者所在课题组正在开展的关于可降解生物弹性体的研究.
关键词:生物弹性体;降解;进展
分类号:TQ334.1  文献标识码:A

文章编号:1005-4030(2007)02-0047-07

Research Development of Degradable Bioelastomers

LIU Quan-yong  WU Jun-yue  SHI Rui  ZHANG Zi-zheng  LEI Li-juan  ZHANG Li-qun  CHEN Da-fu 

作者简介:刘全勇(1978-),男,湖北麻城人,北京化工大学在读博士研究生,主要从事新型生物材料--可降解聚酯弹性体的研究工作.
作者单位:刘全勇(北京化工大学,先进弹性体材料研究中心,北京,100029) 
     吴珺玥(北京化工大学,先进弹性体材料研究中心,北京,100029) 
     石锐(北京化工大学,先进弹性体材料研究中心,北京,100029) 
     张子政(北京化工大学,先进弹性体材料研究中心,北京,100029) 
     雷丽娟(北京化工大学,先进弹性体材料研究中心,北京,100029) 
     张立群(北京化工大学,先进弹性体材料研究中心,北京,100029) 
     陈大福(北京化工大学,先进弹性体材料研究中心,北京,100029) 

参考文献:

[1]Fisher J P,Timmer M D,Holland T A,Dean D,Engel P S,Mikos A G..Photoinitiated cross-linking of the biodegradable polyester poly(propylene fumarate).Part II:In vitro degradation.Biomacromolecules,2003,4,1335~1342.
[2]Storck M,Orend K H,Schmitzrixen T.Absorbable suture in vascular surgery.Vasc Surg,1993,27,413~424.
[3]Engelmayr G C,Hildebrand D K,Sutherland F W H.A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterials.Biomaterials,2003,24,2523~2532.
[4]Lee S D,Hsiue G H,AQ13 Chang P C T,Kao C.Plasma induced grafted polymerization of acrylic acid and subsequent grafting of collagen onto polymer film as biomaterials.Biomaterials,1996,17:1599~1608.
[5]Amsden B,Wang S,Wyss U.Synthesis and characterization of thermoset biodegradable elastomer based on star-poly(ε-caprolactone-co-D,L-lactide).Biomacromoledules,2004,5,1399~1404.
[6]Puskas J E,Chen Y H.Biomedical application of commercial polymers and novel polyisobutylene-based thermoplastic elastomers for soft tissue replacement.Biomacromolecules,2004,5(4):1141~1154.
[7]Nagata M,Kanechika M,Sakai W,Tsutsumi N.Novel biodegradable network elastometric polyesters from multifunctional aromatic carboxylic acids and polycaprolactone.J Polym Sci Part A Polym Chem,2002,40:4523~4529.
[8]Wang T,Ameer G A,Sheppard B J,Langer R.A tough biodegradable elastomer.Nat Biotechnol,2002,20:602~606.
[9]Sundback C A,Shyu J Y,Wang Y,Faquin W C,Langer R S,Vacanti J P,Hadlock T A.Biocompatibility analysis of poly(glycerol sebacate) as a nerve guide material.Biomaterials,2005,6:5454~5464.
[10]Yang J,Webb A R,Ameer G A.Nobel citric acid-based biodegradable elastomers for tissue engineering.Adv Mater,2004,16:511~516.
[11]Yang J,Webb A R,Pickerill S J,Hageman G.,Ameer G.A.Synthesis and evaluation of poly(diol citrate) biodegradable elastomers.Biomaterials,2006,27:1889~1898.
[12]Kang Y,Yang J,Khan S,Anissian L,Ameer G.A.A new biodegradable polyester elastomer for cartilage tissue engineering.J Biomed Mater Res,2006,77A:331~339.
[13]Yang J,Motlagh D,Allen J B,Webb A R,Kibbe M R,Aalami O,Kapadia M,Carroll T J,Ameer G.A.Modulating expanded polytetrafluoroethylene vascular graft host response via citric acid-based biodegradable elastomers.Adv Mater,2006,in press.
[14]Amsden B,Wang S,Wyss U.Synthesis and characterization of thermoset biodegradable elastomer based on star-poly(ε-caprolactone-co-D,L-lactide).Biomacromoledules,2004,5,1399~1404.
[15]Younes H M,Bravo-Grimaldo E,Amsden B G..Synthesis,characterization and in vitro degradation of a biodegradable elastomer.Biomaterials,2004,25:5261~5269.
[16]Amsden B G,Misra G.,Gu F,Younes H M.Synthesis and Characterization of A Photo-Cross-Linked Biodegradable Elastomer.Biomacromolecules,2004,5:2479~2486.
[17]Gu F,Amsden B,Neufeld R.Sustained delivery of vascular endothelial growth factor using alginate beads.J Control Release,2004,96:463~472.
[18]宋子锋,王晓丽,陈丽然,候信,姚康德.脂肪族聚酯弹性体的合成及其性能研究.高分子通报,2005,5:128~134.
[19]Barham P J,Keller A,Orun E L,Holmes P A.Crystallization and morphology of a bacterial thermoplastic:poly-3-hydroxybutyrate.J Mater Sci,1984,19:2781~2794.
[20]Gagnon K D,Lenz R W,Farris R J,Fuller R C.The mechanical properties of a thermoplastic elastomer produced by the bacterium Pseudomonas oleovorans.Rubber Chem Technol,1992,65:761~777.
[21]Lee S Y,Review Bacterial Polyhydroxyalkanoates.Biotechnol and Bioeng,1996,49:1~14.
[22]Deschamps A A,Grijpma D W,Feijen J.J.Poly(ethylene oxide)/poly(butylenes terephthalate) segmented block copolymers:the effect of copolymer composition on physical properties and degradation behavior.Polymer,2001,42:9335~9345.
[23]Radder A M,Leenders H,Van B C.A.Bone-bonding behaviour of poly(ethylene oxide)-polybutylene terephthalate copolymer coatings and bulk implants:a comparative study.Biomaterials,1995,16(7):507~513.
[24]Bezemer G.J,Van B C A,Ponec M.Biocompatibility of a biodegradable matrix used as a skin substitute:An in vivo evaluation.J Biomed Mater Res,1994,28(5):545~552.
[25]张勇,张爱英,冯增国.聚乙二醇/聚对苯二甲酸丁二醇酯聚醚酯弹性体的合成与表征--不同硬段长度对材料性能的影响.高分子学报,2002,(2):167~171.
[26]Ukielski R.New multiblock terpoly (ester-ether-amide) thermoplastic elastomers with various chemical compositions of ester blocks.Polymer,2000,41:1893~904.
[27]Cohn D,Hotovely-Salomon.Biodegradable multiblock PEO/PLA thermoplastic elastomers:molecular design and properties.Polymer,2005,46:2068~2075.
[28]Voet D,J.G.Voet,Biochemistry,Wiley,New York.1990.
[29]章苏宁,陈涛,林嘉平等.聚肽的结构性能及其在生物材料领域的应用.高分子通报,2004,(3):19~27.
[30]Deming T J.Polypeptide materials:new synthetic methods and applications.Adv Mater,1997,9(4):299~31.
[31]Heller J,Barr J,Ng S Y,Shen H R,Schwach-Abdellaoui K,Emmahl S,Rothen-Weinhold A,Gurny R.Poly(ortho esters)-their development and some recent applications.Eur J Pharm Biopharm,2000,50:121~128.
[32]Sutefuaano E E.Biodegradable thermosetting elastomer.JP.Patent 3128934.
[33]Liu Q Y,Tian M,Ding T,Shi R,Zhang L Q.Preparation and characterization of a biodegradable polyester elastomer with thermal processing abilities.J Appl Polym Sci,2005,98:2033~2041.
[34]Liu Q Y,Tian M,Ding T,Shi R,Feng Y X,Zhang L Q,Chen D F,Tian W.Preparation and characterization of a thermoplastic poly(glycerol-sebacate) elastomer by two-step method.J Appl Polym Sci,2006,in press.
[35]Liu Q Y,Tian M,Shi R,Zhang L Q,Chen D F,Tian W.Research on the structure and properties of thermoplastic poly(glycerol-sebacate) elastomers originating from prepolymers with different molecular weight.J Appl Polym Sci,2006,accepted.
[36]Ding T,Liu Q Y,Shi R,Tian M,Yang J,Zhang L Q.Synthesis,characterization and in vitro degradation study of a novel and rapidly biodegradable elastomer.Polym Degrad Stabil,2006,91:733~739.
[37]Shi R,Liu Q Y,Ding T,Han Y M,Zhang L Q,Chen D F,Tian W.The study of ageing of aoft thermoplastic starch with high glycerol content.J Appl Polym Sci,2006,in press.
[38]Shi R,Ding T,Liu Q Y,Han Y M,Zhang L Q,Chen D F,Tian W.In vitro degradation and swelling behaviour of rubbery thermoplastic starch in simulated body and simulated saliva fluid and effects of the degradation products on cells.Polym Degrad Stabil,2006,in press.

收稿日期:2006年10月15日

出版日期:2007年4月30日